September 10, 2010: Sigma Life Science, the biological products and research services business of Sigma-Aldrich Corporation, has announced the global release of a pioneering range of engineered mammalian cell lines. This new product range combines Sigma’s proprietary CompoZr zinc finger nuclease (ZFN) technology with the company’s extensive experience in gene silencing to offer innovative tools for drug discovery, compound screening and fundamental research applications.
This new range of products includes immortalised cell lines for a broad spectrum of applications, each precisely engineered to help scientists answer specific biological questions. By exploiting the revolutionary genomic editing capabilities of ZFNs, Sigma’s scientists can rapidly manufacture stable cell lines with precise, well characterised genetic manipulations. The program will use ZFNs to incorporate and develop cell lines with a variety of cellular markers expected to aid in compound screening studies and biochemical pathway analysis, as well as specific isogenic lines designed to advance colorectal and breast cancer research. In addition, Sigma offers a custom cell line engineering service, creating bespoke cell lines to match researchers’ applications.
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